Optogenetics Light Delivery Systems - Overview

Optogenetics is a technology that allows targeted, fast control of precisely defined events in biological systems, by delivering optical control at the speed (millisecond scale) and with the precision (cell type–specific) required for biological processing.

As far as optogenetics applications are concerned, LEDs are able to simultaneously meet both the speed and the spatial precision requirements mentioned above. In addition, compared to lasers, LEDs excel in almost every respect: they are cheaper, smaller, more reliable, and easier to control.

Mightex has developed a range of Light Delivery Systems for optogenetics, as described below:

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(1) For in vivo optogenetics, fiber-coupled LEDs are capable of delivering light to the specific cell(s) of interest, without disturbing other cells in the vicinity. Moreover, multiwavelength fiber-coupled LEDs enable one to switch wavelengths (e.g. 470nm and 590nm) of the light delivered to the cell(s) through the same fiber, without the need of any mechanical movement or to physically switch fibers. Mightex’s FCS- and WFC-series fiber-coupled LED sources are designed for such in vivo optogenetics applications. In addition, Mightex has also developed the market-leading turn-key optogenetics starter kit.

(2) For in vitro optogenetics, microscopes are usually used in order to achieve the spatial resolution required to view individual cells, and patterned illuminators are also needed in order to precisely control (i.e. activate/silence) the cells of interest without disturbing other cells within the microscope’s Field of View (FoV). Mightex’s Polygon400 Spatiotemporal Patterned Illuminators are designed for such ex vivo and in vitro optogenetics applications.

For those in vitro applications that do not require precise spatial control, Mightex has the following lower-cost solutions:

a) Precision LED spotlights: https://www.mightexsystems.com/family_info.php?cPath=120_221_225&categories_id=225.
b) Collimated LED sources: https://www.mightexsystems.com/family_info.php?cPath=120_221_224&categories_id=224.


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